Cannabidiol is one of the many cannabinoids present in the cannabis plant that has become famous for its benefits in treating different conditions. However, it is essential to consider what drugs should not be taken with CBD. Although the cannabis plant contains hundreds of cannabinoids, cannabidiol or CBD is amongst the safest. Unlike its THC counterpart, CBD is not psychoactive and can help with different conditions. Plus, nature’s beneficial’s hemp oil reviews consider CBD extremely safe, even more than prescription drugs. However, the use of CBD for the treatment of medical conditions is yet to be approved by the FDA. This is usually a problem for people who intend to start using CBD.

It’s also a really good reason to seek your doctor’s advice first before you start to use any CBD drugs. Like many other medications, CBD can have some adverse effects, and you could fall victim, if you don’t get proper advice from your doctor. Your doctor would probably ask you about your medical history with over the counter medications. They will also need to know if you’re on any prescription drugs currently. These are very important factors to consider before they ascertain potential interactions.

Research shows that CBD can cause problematic interactions with many prescription medications. These effects can be dire to the body system and might aggravate other medical conditions. Although the results of such studies are generally inconclusive, medical professionals advise users to avoid mixing CBD with other drugs. Considering the fact that further research needs to be carried out, it is best to avoid any problems. Although many Cannabidiol reviews show that it is useful, a couple of drugs might not go so well with it.

In this article, we would be educating you on how CBD interacts with different types of drugs. Also, you will get to learn various facts about the effects of drug interactions with CBD.

Why CBD Use Affects Some Drug Types

Before we go on educating you about the potential drug interactions with CBD and its effects on the body, it is essential to touch on the reason it happens in the first place. The first thing you should note is that there can be potential interactions between different prescribed medications. CBD isn’t the only compound to be worried about, which is why you need medical advice before using any drugs. Also, possible interactions can cause one of the drugs to be less effective. For CBD drug interactions, it can cause certain drugs to be either less effective or over sufficient by interacting with the receptors of the endocannabinoid system (ECS) in the body. It also alters the effectiveness of drugs by obstructing the activities of cytochrome P450.

  • Reduced Effect Of CBD Interaction

Cytochrome P450 is a group of enzymes found in the liver that breakdown any form of drugs and toxins that enter into the body. The CYP450 enzymes are crucial to the proper metabolism of different drug types. When CBD interact with these enzymes, they inhibit the metabolic breakdown of drugs. Hence, reducing how certain effective drugs might be. The specific enzyme in this group of enzymes responsible for breaking down different types of drugs is CYP34A.

  • Increased Effect Of CBD Drug Interaction

CBD drug interactions can also exaggerate the effects of drugs on the body. There are certain drugs that are designed to inhibit the metabolic activity of CYP34A. When you take CBD with these types of drugs, they work together as inhibitors of CYP34A, which will make it more inactive. This will lead to your body having a more considerable amount of a specific drug even when you take the right dose. Hence, causing the effects of the drugs to be exaggerated. This process can lead to some awful side effects that might be detrimental, depending on other conditions you might have.

However, these CBD drug interactions are usually noticed when you take a large dose of CBD oils and other products. If you take only small doses, then you most likely won’t have to deal with these interactions. Nevertheless, it is crucial to seek medical advice before taking any CBD related drugs.

List Of Drugs That Should Not Be Taken With CBD & Possible Effects

To help you fully grasp just how important ascertaining the drug interactions of CBD is, we will be enlightening you on the possible effects of certain drug types.

Interaction Between CBD & Diclofenac

One of the significant drugs many people take without a prescription from a doctor is painkillers. A perfect example is a diclofenac, a non-steroidal anti-inflammatory drug prescribed as a pain reliever for arthritis conditions. There is no concrete documentation on CBD’s interaction with diclofenac.

However, many doctors advise taking both medications with caution since there is no concrete evidence yet. Nevertheless, based on how CBD is broken down, there might be no interaction with painkillers that don’t fall within the NSAID category.

Interaction Between CBD And Blood Thinners

Blood thinners like Warfarin are anticoagulants typically used for the treatment of conditions such as deep vein thrombosis. This condition causes blood clots’ formation in the vein, and blood thinners help reduce this process. According to research, taking CBD with a blood thinner like Warfarin can cause bleeding.

Primarily, CBD inhibits the rate of metabolism of blood thinners in the body. This can lead to an exaggerated and prolonged effect of the blood thinners. Thus, causing a patient to bleed continuously until the drug is completely metabolized.

Interaction Between CBD And Drugs For Chemotherapy

Treating cancer comes with a lot of pain, and many studies have shown that the use of cannabinoids like CBD is useful for this pain. Also, it helps cancer patients relax while reducing anxiety. Although this might sound nice, the interaction between CBD and chemotherapy is unfavorable for patients.

The drugs taken for chemotherapy are specifically formulated to kill cancer cells because they increase. In a bid to get rid of cancer cells quickly and prevent a patient’s condition from becoming worse, there are specific doses. An inadequate amount can lead to reduced or increased effects. Many drugs used for chemotherapy are formulated with the intent that they will be broken down before entering the bloodstream.

When you take CBD with a chemotherapy drug, it can lead to an excessive amount of the drug entering the bloodstream at a time. This could lead to a severe toxic reaction such as slowed or zero heart rate, decreased level of consciousness, etc.

Interaction Between CBD And Calcium Channel Blockers/ Blood Pressure Medication

Calcium channel blockers are crucial for the treatment of conditions such as cluster headaches, high blood pressure, heart arrhythmia, etc. These groups of drugs block the movement of calcium through calcium channels in different parts of the body. Taking CBD with blood pressure drugs like amlodipine can cause an excessive amount to remain in the bloodstream.

This is caused by the inability of the CYP450 enzyme to catalyze the breakdown of the drug. Since calcium channel blockers work to decrease the pumping rate of the heart, having too much in your system can cause side effects like;

  • Difficulty in breathing
  • Lightheadedness
  • Confusion
  • Slow heartbeat
  • Nausea
  • Irregular heartbeat
  • Slurred speech

If you happen to notice any of these symptoms, then you should seek medical attention immediately.

Interaction Between CBD & Theophylline (Bronchodilator)

Bronchodilators are medications formulated for the treatment of lung diseases such as asthma, bronchitis, etc. Theophylline is one of those drugs, and it acts by relaxing the airways of the lungs, which helps in opening it up. This makes it easier for patients to breathe and prevent symptoms of wheezing and shortness of breath.

According to research, taking CBD alongside bronchodilators like theophylline may hasten its metabolic breakdown. This renders the drug ineffective for asthma patients. However, it is unclear if this interaction is a result of smoking cannabis. Since smoke can irritate the airways, it is most likely that smoking cannabis will irritate the lung’s airways.

Interaction Between CBD And HIV Antivirals

Living with HIV can come with significant detrimental symptoms such as weight loss, peripheral neuropathy (nerve pain), lung diseases, weakness, etc. Antiviral drugs work by blocking the receptors with which the HIV virus binds to healthy cells in the body. Although CBD isn’t used to treat HIV, it can help with the symptoms associated with the virus.

According to research, the interaction between the cannabidiol CBD and antiviral medications enhances the effects of CBD. However, smoking cannabis can lead to severe damages to the lungs.

Interaction Between CBD & Clobazam (Seizure Medication)

Clobazam is a benzodiazepine famous for the treatment of seizures in conditions like the Lennox Gastaut Syndrome. CBD is also FDA approved for the treatment of this syndrome in a drug called Epidolex. If you take CBD and seizure medications like clobazam, the drug’s effects and side effects are exaggerated.

Taking both drugs causes a triple fold production in the plasma concentration of the active metabolite in the drug. This prevents seizures effectively. However, the downside to this is that the side effect (sedation) associated with using this drug is also exaggerated. It is, therefore, important to always seek advice from your doctor before taking both.

Other medications that should not be taken with cannabidiol CBD, because of how it might react are;

  • Steroids & Corticosteroids: Cortisone, Hydrocortisone, prednisone, etc
  • Antihistamines: brompheniramine, chlorpheniramine, diphenhydramine, loratadine, etc.
  • HMG CoA reductase inhibitors (Statins): atorvastatin, lovastatin, pitavastatin, rosuvastatin, etc.
  • Prokinetics (Drugs For Motility): domperidone, levosulpiride, pruorpride, and renzapride.
  • Immune modulators: Immune globulins, immunostimulants (bacterial and viral vaccines), and immunosuppressive agents.
  • Antibiotics: Levofloxacin, amoxicillin, cephalexin, ciprofloxacin, metronidazole, sulfamethoxazole-trimethoprim, amoxicillin-clavulanate, etc.
  • Antipsychotic: aripiprazole, cariprazine, lurasidone, quetiapine, ziprasidone, risperidone, etc.
  • Antidepressants: citalopram, fluoxetine, paroxetine, vortioxetine, vilazodone, etc.
  • Anesthetics: barbiturates, methohexital, etomidate, ketamine, propofol, etc.
  • Beta blockers: Atenolol, betaxolol, fumarate, carvedilol, labetalol, nadolol, penbutolol, propranolol, timolol, etc.
  • Proton-Pump Inhibitors (PPIs): omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole, and dexlansoprazole
  • Angiotension II Blockers: azilsartan, eprosartan, irbesartan, candesartan, losartan, valsartan olmesartan, and telmisartan
  • Oral Hypoglycemic Agents: meglitinides, sulfonylureas, biguanides, α-Glucosidase inhibitors, thiazolidinediones, DPP-4 inhibitors, cycloset, and SGLT2 inhibitors
  • Sulfonylureas: MicronaseMicronase, Glynase, Amaryl, diabinese, tolinase, glucotrol, and tolbutamide

CBD’s Bioavailability & How It Affects Drug Interaction

A crucial factor to consider as we enlighten you on the interaction between CBD and other medications is its bioavailability. The bioavailability of different drugs simply means how much of the drug is absorbed to offer an effect. For many prescription drugs, the bioavailability is already ascertained before a dosage is given.

For CBD, navigating the bioavailability is a bit tricky, as it depends on the method of consumption and the concentration of the product. CBD exists in different products, and each administration process offers different bioavailability. For instance, injecting CBD into your body will take it directly into your bloodstream via your veins. However, this isn’t advisable when you are on other drugs.

Vaping, which entails inhaling the CBD directly into your lungs, is also a great way to get it to the bloodstream quickly. Oral consumption such as CBD edibles and sweets will be broken down by digestive enzymes first, before reaching the bloodstream. Hence, causing them to have a reduced bioavailability and effect in the body.

The safest options are topical options like CBD oil, CBD gels, and creams, which you apply on the affected spots. These options usually have a small concentration of CBD & THC, which will give mild effect and interaction with other drugs. The bioavailability of CBD in the bloodstream could also help answer different questions such as “does CBD oil help balance hormones?”

The effectiveness of CBD oil is dependent on its bioavailability in the bloodstream after administration.

Grapefruit Warning: Why It Is Important

Trying to ascertain what medications are safe for use with CBD can be very difficult. While there is still a lot of research going on, there is one specific way that can help. Always check your medications for a grapefruit warning. A lot of prescription medications come with a grapefruit warning.

The grapefruit warning is essentially an instruction that indicates a drug interaction with grapefruit and its juice. So, users are advised not to consume grapefruit and grapefruit juice when they take a specific drug. Research carried out by the Food and Drug Administration (FDA) shows that eating grapefruit or drinking its juice can increase the concentration of a specific drug in the bloodstream. This could lead to dangerous side effects.

Further studies have found that over 85% of medications interact with grapefruit and many other citrus fruits. This is because citrus fruits contain furanocoumarins; a chemical that stops the activity of enzyme CYP34A. Hence, it reduces the metabolic rate of drugs the same as when you take CBD.

So, if you are about to take a medication and it has a grapefruit warning, then it will definitely interact with CBD.

Why You Should See Your Doctor Before Taking CBD

CBD oil might not help in the treatment of a specific condition, however, research has shown that it is excellent for alleviating the associated symptoms. Medical conditions are usually associated with inflammation, nausea, pains, weight loss, and so many others, and CBD can reduce these symptoms. However, when you take into consideration the fact that there are so many unknown interactions with the cannabinoid, you should know to take caution.

It is important for you to see a doctor before starting any CBD product. They will be able to ascertain what type of product, the dosage, and the time frame that is safe for your medications. The type of CBD product you intend to use is an important factor to consider. This is because the concentration of each product varies, and as such it influences interactions.


CBD is a powerful compound that can impact different systems in the body at a time. Its amazing benefits are the exact reasons for numerous questions such as “does CBD oil help with enlarged prostate?” and many others. Even though the benefits of CBD oil are undeniably impressive, further studies have shown inconsistent results as regards its interaction with different drugs.

The interaction between CBD and other drugs can reduce or increase the effect of many drugs by inhibiting cytochrome P450. When drugs are not metabolized properly by CYP450, it can lead to a higher concentration of a specific drug in the bloodstream. This could lead to adverse side effects detrimental to your system. To prevent this it is important to seek advice from a professional. Also, you can check your medication for a grapefruit warning. If you find this, then you might want to avoid any CBD medication.


Is It Safe To Take CBD Oil With Tramadol?

It is safe to use CBD oil with tramadol. However, using high doses of CBD may reduce the analgesic effect of tramadol.

According to research, taking Cannabidiol with tramadol offers a form of synergistic analgesic effect against a different form of pain. Also, recent studies have found that patients using opioids like tramadol tend to reduce their doses when cannabidiol is included. Thus reducing the body’s tolerance for these forms of drugs.

How long does it take for CBD Oil To Work For Joint Pain?

The effects of CBD oil for joint pain can be felt within 15-20 minutes if you use a CBD topical gel or cream on the affected area.

As mentioned before, the effect of CBD is usually dependent on the means of consumption.

  • For joint pain, a topical gel, cream, or balm takes about 10 minutes to work.
  • Oral consumption of edibles takes about 30 minutes to 2 hours
  • Vaping gives a quicker relief in 5 minutes
  • Sublingual drops take about 15- 30 minutes

All you need to do is get the best option that works for you, depending on how severe your condition is.

Does CBD oil Interact With Blood Pressure Medications?

CBD can interact with blood pressure medications causing them to be less effective. This can lead to irregular/ slow heartbeats, nausea, confusion, etc.

Blood pressure drugs work by decreasing the heart rate to regulate the pumping of blood all over the body. When CBD interferes with these drugs’ metabolism, it causes a large concentration of the drug to remain in the bloodstream for a long while. Thus, reducing the heart rate continuously until only trace amounts of the drug is left in your system.

What Medication Interacts With CBD Oil?

The medications that interact with CBD oils are:

  • Blood thinners (Warfarin)
  • Blood pressure medications (Calcium channel blockers)
  • Bronchodilators
  • Non-steroidal Anti Inflammatory Drugs (NSAIDs like diclofenac)
  • Antidepressants (such as fluoxetine, or Prozac)
  • Steroids (Cortisone, Hydrocortisone)
  • Antipsychotics, Benzodiazepines (Medication to induce sleep)
  • Antibiotics (Levofloxacin, erythromycin)